The West Coast premiere of Evan Smith’s “The Savannah Disputation,” a comedy about serious matters of faith, is highly recommended. It concerns two aging Roman Catholic parishioners, Mary and Margaret, who attend Father Murphy’s church. Mary (Nancy Robinette) is especially cantankerous, having had a youthful marriage that failed due to her husband’s infidelity. Her never-married sister, Margaret (Mikel Sarah Lambert), enjoys a simple, uncomplicated life, never questioning the rituals and routines of faith and existence. A long way from “Sister Mary Ignatius Explains It All for You,” “The Savannah Disputation” is intelligent, profound and at the same time excruciatingly funny. The playwright refuses to take sides, and life itself is called into question. It’s a terrific play and a marvelous production, sublimely acted. As usual, the Globe production values are tops, with scenic design by Deb O, costumes by Judith Dolan, lighting by Alan Burrett (professor of design at UCSD) and sound by Paul Peterson. Even though the setting is contemporary Savannah, the attitudes, the furnishings and the disputation itself suggest earlier times in long ago places. “Savannah Disputation” continues at 7 p.m. Tuesdays, Wednesdays and Sundays; 8 p.m. Thursdays through Saturdays; 2 p.m. Saturdays and Sundays through Nov. 1 at the Old Globe Arena Stage at Copley Auditorium, San Diego Museum of Art, Balboa Park. For tickets ($29-$62), visit www.theoldglobe.org or call (619) 23-GLOBE.